Publications
2022
Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular toxicity. Nature Communications
Wang MS, Hu Y, Sanchez EE, Xie X, Roy NH, de Jesus M, Winer BY, Zale EA, Jin W, Sachar C, Lee JH, Hong Y, Kim M, Kam LC, Salaita K, Huse M
TrackMate 7: integrating state-of-the-art segmentation algorithms into tracking pipelines. Nature Methods
Ershov D, Phan MS, Pylvanainen JW, Rigaud SU, Le Blanc L, Charles-Orszag A, Conway JRW, Laine RF, Roy NH, Bonazzi D, Dumenil G, Jacquemet G, Tinevez JY
A murine model of X-linked moesin-associated immunodeficiency (X-MAID) reveals defects in T cell homeostasis and migration . Frontiers in Immunology
Avery L, Robertson TF, Wu CF, Roy NH, Chauvin SD, Perkey E, Vanderbeck A, Maillard I, and Burkhardt JK
2021
Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7. Cell Host & Microbe
Guérin A, Roy NH, Kugler EM, Berry L, Burkhardt JK, Shin JB, Striepen B
Antigen-independent activation enhances the efficacy of 41BB co-stimulated CD22 CAR T cells. Nature Medicine
Singh N, Frey NV, Engels B, Barrett DM, Shestova O, Ravikumar P, Cummings KD, Le YG, Pajarillo R, Chun I, Shyu A, Highfill SL, Price A, Zhao L, Peng L, Granda B, Ramones M, Christian DA, Perazzeli J, Lacey SF, Roy NH, Burkhardt JK, Colomb F, Damra M, Abdel-Mohsen M, Lui T, Lui D, Standley DM, Young RM, Brogdon JL, Grupp SA, June CH, Maude SL, Gill S, and Ruella M
Lymphocyte egress signal Sphingosine-1-Phosphate promotes ERM-guided, bleb-based migration. Journal of Cell Biology
Robertson TF, Chengappa P, Gomez-Atria D, Wu CF, Avery L, Roy NH, Maillard I, Petrie RJ, and Burkhardt JK
2020
Automated cell tracking using StarDist and Trackmate. F1000 Research
Fazeli E, Roy NH, Follain G, Laine RF, von Chamier L, Hanninen P, Eriksson JEH, Tinevez JY, Jacquemet G
LFA-1 signals to promote actin polymerization and upstream migration in T cells. Journal of Cell Science
Roy NH, Kim SHJ, Buffone A Jr, Blumenthal D, Huang B, Agarwal S, Schwartzberg PL, Hammer DA, Burkhardt JK
CrkL is required for donor T cell migration to GVHD Target organs. Oncotarget
Roy NH, Mammadli M, Burkhardt JK, Karimi M
Ectromelia-encoded virulence factor C15 specifically inhibits antigen presentation to CD4+ T cells post peptide loading. PloS Pathogens
Forsyth KS, Roy NH, Peauroi E, DeHaven BC, Wold ED, Hersperger AR, Burkhardt JK, Eisenlohr LC
2018
Crk adaptor proteins mediate actin-dependent T cell migration and mechanosensing induced by the integrin LFA-1. Science Signaling
Roy NH, Mackay JL, Robertson TF, Hammer DA, Burkhardt JK
The Actin Cytoskeleton: A Mechanical Intermediate for Signal Integration at the Immunological Synapse. Frontiers in Cell and Developmental Biology
Roy NH and Burkhardt JK
Integrins Modulate T Cell Receptor Signaling by Constraining Actin Flow at the Immunological Synapse. Frontiers in Immunology
Jankowska JI, Williamson EK, Roy NH, Chandra V, Burkhardt JK
Murine Chronic Graft-Versus-Host Disease Proteome Profiling Discovers CCL15 as a Novel Biomarker in Patients. Blood
Du J, Flynn R, Paz K, Ren H, Ogata Y, Zhang Q, Gafken PR, Storer BE, Roy NH, Burkhardt JK, Mathews W, Tolar J, Lee SJ, Blazar BR, Paczesny S
2009-2017
Embracing the Enemy: Cell-to-Cell Force Transmission Enhances Cytotoxicity. Developmental Cell
Roy NH and Burkhardt JK
Crk Proteins selectively regulate T cell migration into inflamed tissues. Journal of Clinical Investigation
Huang Y, Clarke F, Karimi M, Roy NH, Williamson EK, Okumura M, Mochizuki K, Chen EJ, Park TJ, Debes GF, Zhang Y, Curran T, Kambayashi T, Burkhardt JK.
HIV-1-Induced Small T Cell Syncytia Can Transfer Virus Particles to Target Cells through Transient Contacts. Viruses
Symeonides M, Murooka TT, Bellfy LN, Roy NH, Mempel TR, Thali M
Vpu is the main determinant for tetraspanin downregulation in HIV-1 infected cells. Journal of Virology
Lambele M, Koppensteiner H, Symeonides M, Roy NH, Chan J, Schindler, Thali M
Ezrin is a component of the HIV-1 virological presynapse and contributes to the inhibition of cell-cell fusion. Journal of Virology
Roy NH, Lambele M, Chan J, Symeonides M, Thali M
Tetraspanin CD82 restrains pathological angiogenesis by altering lipid raft clustering and CD44 trafficking in endothelial cells. Circulation
Wei Q, Zhang F, Richardson MM, Roy NH, Rodgers W, Liu Y, et al.
Evidence showing that tetraspanins inhibit HIV-1 induced cell- cell fusion at a post-hemifusion stage. Viruses
Symeonides M, Lambele M, Roy NH, Thali M
SNAP-tag technology optimized for use in Entamoeba histolytica. Plos One
Sateriale A, Roy NH, Huston CD
Clustering and mobility of HIV-1 Env at viral assembly sites predict its propensity to induce cell-cell fusion. Journal of Virology
Roy NH, Chan J, Lambele M, Thali M
HIV-1 assembly differentially alters dynamics and partitioning of tetraspanins and raft components. Traffic
Krementsov DN, Rassam P, Margeat E, Roy NH, Schneider-Schaulies J, Milhiet PE, Thali M
Tetraspanins regulate cell-to-cell transmission of HIV- 1. Retrovirology
Krementsov DN, Weng J, Lambelé M, Roy NH, Thali M
Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cells. Journal of Virology
Weng J, Krementsov DN, Khurana S, Roy NH, Thali M